association study of rs1333040 and rs1004638 polymorphisms in the 9p21 locus with coronary artery disease in southwest of iran
نویسندگان
چکیده
background: coronary artery disease (cad) is a multifactorial and heterogenic disease. recently, genome-wide association studies have reported that rs1333040 (c/t) and rs1004638 (a/t) single nucleotide polymorphisms (snps) in the 9p21 locus have very strong association with cad. this study aimed to examine these associations in southwest of iran. methods: blood samples were collected from 200 cad patients and 110 healthy individuals with no cad. the association of two snps with cad was evaluated by pcr and restriction fragment length polymorphism. results: chi-square test showed no association between rs1333040 snp and cad (x2: 4.66, df: 2, p=0.09). also, there was no association between rs1004638 snp and cad (x2: 0.27, df: 2, p=0.88). conclusion: no association was observed between rs1333040 and rs1004638 snps in the 9p21 region and cad in southwest of iran.
منابع مشابه
Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran
Background: Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran. Methods: Blood samples were collected from 200 C...
متن کاملAssociation Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran
BACKGROUND Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran. METHODS Blood samples were collected from 200 C...
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15 صفحه اولassociation study between coronary artery disease and rs1333049 and rs10757274 polymorphisms at 9p21 locus in south-west iran
objective: coronary artery disease (cad) is a multi-factorial and heterogenic disease with atherosclerosis plaques formation in internal wall of coronary artery. plaque formation results to limitation of the blood reaching to myocardium leading to appearance of some problems, such as ischemia, sudden thrombosis veins and myocardial infarction (mi). several environmental and genetic factors are ...
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BACKGROUND AND OBJECTIVES Genetic predisposition is an important risk factor for coronary artery disease (CAD). In this study, we aimed to evaluate the impact of rs10757274 and rs2383206 polymorphisms in chromosome 9p21 on presence and severity of CAD in a Turkish population. SUBJECTS AND METHODS A total of 646 patients who underwent coronary angiography were included in this study. Coronary ...
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عنوان ژورنال:
iranian biomedical journalجلد ۲۰، شماره ۲، صفحات ۱۲۲-۱۲۷
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